Abstract Radical cystectomy (RC) with urinary diversion remains the gold-standard treatment for muscle-invasive bladder cancer (MIBC), yet its implementation in Sub-Saharan Africa is hindered by late-stage presentation, limited surgical expertise, and inadequate perioperative care.These challenges contribute to higher morbidity and poorer survival
Arachidonic acid lipoxygenases (ALOXs) play important roles in cell differentiation and in the pathogenesis of cardiovascular, hyperproliferative, neurodegenerative, and metabolic diseases.The human genome involves six intact ALOX genes and knockout studies of the corresponding mouse orthologs indicated that the coding multiplicity of ALOX isoforms
Pleiotropy arises when a locus influences multiple traits.Rich GWAS findings of various traits in the past decade reveal many examples of this phenomenon, suggesting the wide existence of pleiotropic effects.What underlies this phenomenon is the biological connection among seemingly unrelated traits/diseases.Characterizing the molecular mechanisms
Food allergy, an adverse immune reaction triggered by commonly innocuous food proteins, is a health problem that affects Paper Products Soccer - Balls millions of people worldwide (around 10% of the global population), and the most recent reports suggest its increasing progression [.].